Knowledge gaps and resulting uncertainties in exploring future interactions between nature and society are substantial because integrated assessments of future impacts on nature, nature’s contributions to people and a good quality of life that take account of the complex interdependencies in human and environmental systems are rare (well established) (5.6.2). Very few studies were available for Central Asia and to a lesser extent for Eastern Europe (well established) (5.6.2). Less information was also available for marine systems than for terrestrial and freshwater systems (well established) (5.6.2). Few integrated scenario and modelling studies include indicators of nature’s nonmaterial contributions to people and good quality of life (5.3.2, 5.5.1, 5.6.2) and therefore existing assessments of synergies and trade-offs are limited in the interactions and feedbacks they represent (well established) (5.3.2). No studies were found that assessed future flows of nature’s contributions to people across countries, which would have been important to assess the impacts of the scenarios and pathways for Europe and Central Asia on other parts of the world (well established) (5.6.2). There is also a significant gap in the current literature in recognizing the diversity of values, with the focus being mainly on instrumental values (well established) (5.6.2). Finally, scenario and modelling studies include many uncertainties in their projections of the future resulting from input data, scenario assumptions, model structure and propagation of uncertainties across the integrated components of the systems, which should be borne in mind when interpreting their results (well established).